Eph must choose between Zack's safety and the safety of the citizens of NYC. Meanwhile, his relationship with Nora reaches a critical impasse, and Gus and Angel assemble an unlikely gang of Sun-hunters. A thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.