The random escapades of Stan Smith (Seth MacFarlane), an extreme right wing CIA agent dealing with family life and keeping America safe, all in the most absurd way possible. Stan's ditzy wife, Francine (Wendy Schaal), has an unfaltering loyalty that allows her to turn a blind eye toward Stan's unabashed arrogance. Meanwhile, Stan constantly butts heads with his 18-year-old daughter and left-wing activist, Hayley (Rachael MacFarlane), who knows just how to push her father's buttons whether it's by helping the homeless, demanding women's rights or supporting gun control. Hayley's 14-year-old brother is the geeky yet cocky Steve (Scott Grimes), a kid who spends his time playing Dungeons & Dragons and obsessing about the opposite sex. The Smith cabinet is rounded out by two rather unconventional members. There's the selfish and sarcastic space alien, Roger (Seth MacFarlane), who lives in the attic and loves to play dress-up; and Klaus (Dee Bradley Baker), an attention-starved goldfish with the brain of a German guy who is always willing to vocalize his opinions regardless of whether anyone is listening. This eccentric family full of radically different personalities is just trying to find a way to love and trust one another in a bi-partisan way. And with a guy like Stan in charge of national security, it's guaranteed to be one hilarious ride.
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