Dutch fights for her life against Eichhorst as Fet, Nora, and Eph frantically search the city for her. Setrakian confronts an old acquaintance on his search for the Occido Lumen, while Gus helps the Guptas escape across the border to safety. A thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.